L-苏糖, L-Threose

L-Threose is a sugar molecule that is used as a structural component of DNA and RNA. It is also an important part of the energy metabolism in cells. L-Threose can be enzymatically inactivated by glycosidases, which are enzymes that hydrolyze glycosidic bonds. The inhibition of glycosidases by L-threose may be useful for the prevention or treatment of diseases associated with enzyme activity, such as diabetes mellitus type II. L-Threose has been shown to have inhibitory properties against sephadex G-100, a membrane protein found in bacteria. L-Threose may be useful as a control agent for research into the response element of polymerase chain reaction (PCR).

Title: L-Threose

CAS Registry Number: 95-44-3

CAS Name: (2R,3S)-2,3,4-Trihydroxybutanal

Molecular Formula: C4H8O4

Molecular Weight: 120.10

Percent Composition: C 40.00%, H 6.71%, O 53.29%

Literature References: By degradation of L-xylose through the oxime and tetraacetyl-L-xylononitrile to L-threose diacetamide: Hockett et al., J. Am. Chem. Soc. 60, 278 (1938); from D-glucitol: Hutson, Weigel, J. Chem. Soc. 1961, 1546.

Properties: Shows mutarotation; final [a]D20 +13.2° (c = 4.5). Sol in water.

Optical Rotation: [a]D20 +13.2° (c = 4.5)

Derivative Type: Phenylosazone

Molecular Formula: C16H18N4O2

Molecular Weight: 298.34

Percent Composition: C 64.41%, H 6.08%, N 18.78%, O 10.73%

Properties: Dec 162°.