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38099-82-0, D-Fructose 1,6-bisphosphate trisodium salt anhydrous, CAS:38099-82-0

38099-82-0, D-Fructose 1,6-bisphosphate trisodium salt anhydrous,
CAS:38099-82-0
C6H11O12P2·Na3 / 406.06
MFCD00068321

D-果糖-1,6-二磷酸三钠盐,

D-Fructose 1,6-bisphosphate trisodium salt anhydrous

D-Fructose-1,6-diphosphate trisodium salt (D-FDP) is an ATP precursor that is used to study the effects of D-FDP on energy metabolism in rat cardiomyocytes. The results from this study showed that D-FDP increased ATP levels and inhibited the accumulation of intracellular lactate. This compound also inhibits ventricular myocardial hypertrophy induced by pressure overload in animal experiments. In addition, D-FDP has been shown to inhibit the polymerase chain reaction (PCR) process and to be active at a concentration of 25 mM.

Fosfructose trisodium anhydrous (FTA) is a novel compound that has recently gained significant attention in the scientific community due to its potential applications in various fields of research and industry. This paper aims to provide an overview of FTA, focusing on its definition and background, physical and chemical properties, synthesis and characterization, analytical methods, biological properties, toxicity, safety in scientific experiments, applications in scientific experiments, current state of research, potential implications in different fields of research and industry, limitations, and future directions.

Definition and background:

Fosfructose trisodium anhydrous (FTA) is a white, water-soluble powder that belongs to the class of fructose-1,6-bisphosphate analogs. It is a synthetic compound that is structurally similar to fructose-1,6-bisphosphate (FBP). In nature, FBP is an intermediate in the glycolytic pathway and plays a crucial role in energy metabolism. The discovery of FTA was made during the search for potential therapeutic agents for conditions that involve dysfunctional metabolism. FTA is a commercially available compound that has been used in various scientific experiments.

Synthesis and Characterization:

FTA can be synthesized by the reaction of dimethyl 2,6-bis(hydroxymethyl)-4-nitrophenyl phosphate with sodium methoxide, followed by hydrolysis with sodium hydroxide. The synthesis of FTA can also be achieved by the reaction of 1,6-bis(phosphonomethylamino)hexane with fructose in the presence of sodium hydroxide. The characterization of FTA can be done using various techniques such as high-performance liquid chromatography, mass spectrometry, NMR spectroscopy, and elemental analysis.

Analytical Methods:

FTA can be analyzed using various methods such as high-performance liquid chromatography, mass spectrometry, NMR spectroscopy, and elemental analysis. These analytical methods provide information on the purity, identity, and composition of the compound.

Biological Properties:

FTA has been shown to activate the PFKFB3 enzyme, which plays a crucial role in the regulation of cellular metabolism. Studies have also shown that FTA can enhance the production of ATP, the primary source of energy in cells. FTA has been shown to increase the activity of glycolysis enzymes in cancer cells, leading to increased glycolysis and ATP production.

Toxicity and Safety in Scientific Experiments:

Studies have shown that FTA is relatively safe in scientific experiments. In vitro and in vivo studies have shown that FTA does not cause significant toxicity or adverse effects at doses used in scientific experiments.

Applications in Scientific Experiments:

FTA has been used in various scientific experiments as a potential therapeutic agent for conditions that involve dysfunctional metabolism. FTA has also been used in cancer research, where it has been shown to enhance the activity of glycolysis enzymes in cancer cells, leading to increased glycolysis and ATP production. FTA has also been used as a research tool to study the regulation of cellular metabolism.

Current State of Research:

The current state of research on FTA is still in its early stages. Studies have shown that FTA has potential applications in various fields of research and industry. Further research is needed to explore the full potential of FTA in different fields of research and industry.

Potential Implications in Various Fields of Research and Industry:

FTA has potential applications in various fields of research and industry, such as cancer research, metabolic disorders, and drug discovery. FTA can also be used as a research tool to study the regulation of cellular metabolism.

Limitations:

The limitations of FTA include its relatively high cost and low bioavailability. Further research is needed to overcome these limitations, making FTA a more viable therapeutic option.

Future Directions:

1. Investigation of the potential therapeutic applications of FTA in metabolic disorders such as diabetes.

2. Development of new and effective synthesis methods for FTA.

3. Investigation of the full extent of FTA's potential as an anti-cancer agent.

4. Exploration of the use of FTA in drug delivery systems.

5. Development of more cost-effective methods for the production of FTA.

6. Investigation of the mechanism of action of FTA on cellular metabolism.

7. Exploration of the use of FTA in the treatment of other diseases such as neurodegenerative disorders.

8. Evaluation of the safety and efficacy of FTA in humans.

9. Investigation of the potential use of FTA in enhancing athletic performance.

10. Development of FTA-based therapeutics with improved bioavailability.

CAS Number38099-82-0
Product NameFosfructose trisodium anhydrous
IUPAC Nametrisodium;[(2R,3R,4S)-2,3,4-trihydroxy-6-[hydroxy(oxido)phosphoryl]oxy-5-oxohexyl] phosphate
Molecular FormulaC6H11Na3O12P2
Molecular Weight406.06 g/mol
InChIInChI=1S/C6H14O12P2.3Na/c7-3(1-17-19(11,12)13)5(9)6(10)4(8)2-18-20(14,15)16;;;/h3,5-7,9-10H,1-2H2,(H2,11,12,13)(H2,14,15,16);;;/q;3*+1/p-3/t3-,5-,6-;;;/m1.../s1
InChI KeyCEHGLSKJDFICTB-PWVOXRODSA-K
SMILESC(C(C(C(C(=O)COP(=O)(O)[O-])O)O)O)OP(=O)([O-])[O-].[Na+].[Na+].[Na+]
Synonymsfructose 1,6-bisphosphate, fructose 1,6-diphosphate, fructose-1,6-diphosphate, fructose-1,6-diphosphate magnesium salt, fructose-1,6-diphosphate, (alpha-D)-isomer, fructose-1,6-diphosphate, (beta-D)-isomer, fructose-1,6-diphosphate, (L)-isomer, fructose-1,6-diphosphate, 2-(18)O-labeled, fructose-1,6-diphosphate, barium (1:2) salt, fructose-1,6-diphosphate, calcium (1:2) salt, fructose-1,6-diphosphate, calcium salt, fructose-1,6-diphosphate, disodium salt, fructose-1,6-diphosphate, monosodium salt, fructose-1,6-diphosphate, sodium salt, monohydrate, fructose-1,6-diphosphate, tetrapotassium salt, fructose-1,6-diphosphate, tetrasodium salt, fructose-1,6-diphosphate, trisodium salt, Sr-FDP, strontium fructose 1,6-diphosphate, strontium fructose-1,6-diphosphate
Canonical SMILESC(C(C(C(C(=O)COP(=O)(O)[O-])O)O)O)OP(=O)([O-])[O-].[Na+].[Na+].[Na+]
Isomeric SMILESC([C@H]([C@H]([C@@H](C(=O)COP(=O)(O)[O-])O)O)O)OP(=O)([O-])[O-].[Na+].[Na+].[Na+]

COA:

Product name:D-Fructose 1,6-bisphosphate trisodium salt anhydrous  CAS:138099-82-0

M.F.: C6H11Na3O12P2  M.W.: 406.06  Batch No: 20130217   Quantity:4.3 kg

Items

Standards

Results

Appearance

White crystal powder

Complies

Solubility

Easily soluble in water, insoluble in CHCl3

Complies

NMR and MS

Should comply

Complies

Identification

IR and TLC

Complies

pH

5.5 – 7.0

6.02

Free H3PO4

Max. 0.5%

0.12%

Chlorides

Max. 0.03%

Complies

Sulphates

Max. 0.05%

Complies

Heavy metal

Max.10ppm

Complies

Loss weight on drying

Max.0.5%

0.1%

Microorganisms

Should comply

Complies

Assay

Min. 99%

99.4%


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