29899-95-4, Clobenoside, Floganol, Arvigol , CAS:29899-95-4

29899-95-4, Clobenoside,
Floganol,
Arvigol ,
CAS:29899-95-4
C25H32Cl2O6 / 499.424

氯苄葡甙, 氯苄葡苷,Clobenoside, Floganol, Arvigol

Clobenoside, a chloro-containing glucofuranoside, is a non-steroidal anti-inflammatory agent that has also been found to have an edema-protective effect and while not influencing blood pressure nor heart rat, and did not produce any direct vasoactive effects.

Title: Clobenoside

CAS Registry Number: 29899-95-4

CAS Name: Ethyl 5,6-bis-O-[(4-chlorophenyl)methyl]-3-O-propyl-D-glucofuranoside

Additional Names: ethyl 3-O-n-propyl-5,6-di-O-(4-chlorobenzyl)-D-glucofuranoside

Manufacturers' Codes: ZY-15028

Trademarks: Arvigol (Zyma); Floganol (Zyma)

Molecular Formula: C25H32Cl2O6

Molecular Weight: 499.42

Percent Composition: C 60.12%, H 6.46%, Cl 14.20%, O 19.22%

Literature References: Congener of tribenoside, q.v. Prepn: NL 6812906; A. Rossi, US 3542761 (1969, 1970 both to Ciba). Pharmacology and bioavailability in cats: G. Hennings et al., Arzneim.-Forsch. 35, 498 (1985). Effect on glycoprotein biosynthesis in vitro: W. Reutter, C. Bauer, Adv. Enzyme Regul. 24, 405 (1985). Mechanism of action study: D. Araujo et al., Arch. Int. Pharmacodyn. 277, 192 (1985).

Properties: Faintly yellowish oil, [a]D20 -17 ±1° (c = 1 in chloroform). Poorly sol in water.

Optical Rotation: [a]D20 -17 ±1° (c = 1 in chloroform)

Therap-Cat: Vasoprotectant.

Keywords: Vasoprotectant.

CAS Number	29899-95-4
Product Name	(2S,3S,4S,5S)-5-[1,2-bis[(4-chlorophenyl)methoxy]ethyl]-2-ethoxy-4-propoxyoxolan-3-ol
IUPAC Name	(3R,4R,5R)-5-[1,2-bis[(4-chlorophenyl)methoxy]ethyl]-2-ethoxy-4-propoxyoxolan-3-ol
Molecular Formula	C25H32Cl2O6
Molecular Weight	499.42 g/mol
InChI	InChI=1S/C25H32Cl2O6/c1-3-13-31-24-22(28)25(30-4-2)33-23(24)21(32-15-18-7-11-20(27)12-8-18)16-29-14-17-5-9-19(26)10-6-17/h5-12,21-25,28H,3-4,13-16H2,1-2H3/t21?,22-,23-,24-,25?/m1/s1
InChI Key	UOYOWSGCMGEQHC-MSEXXDKFSA-N
SMILES	CCCOC1C(C(OC1C(COCC2=CC=C(C=C2)Cl)OCC3=CC=C(C=C3)Cl)OCC)O
Solubility	Soluble in DMSO
Synonyms	1-O-ethyl-5,6-bis-O-(4-chlorobenzyl)-3-O-propyl-D-glucofuranoside, clobenosid, clobenoside
Canonical SMILES	CCCOC1C(C(OC1C(COCC2=CC=C(C=C2)Cl)OCC3=CC=C(C=C3)Cl)OCC)O
Isomeric SMILES	CCCO[C@@H]1[C@H](C(O[C@@H]1[C@@H](COCC2=CC=C(C=C2)Cl)OCC3=CC=C(C=C3)Cl)OCC)O