253328-56-2, 1,2-O-Isopropylidene-α-D-glucofuranose, CAS:253328-56-2

253328-56-2, 1,2-O-Isopropylidene-α-D-glucofuranose,
CAS:253328-56-2
C9H16O6 / 220.22
MFCD00063244

1,2-O-Isopropylidene-a-D-glucofuranose

单丙酮葡萄糖，

1,2-o-Isopropylidene-α-D-glucofuranose is a potent inhibitor of xylan, which is essential for the growth and development of cancer cells. This compound has been shown to inhibit the activity of several kinases involved in cancer cell proliferation, including protein kinase C and acetylcholine kinase. 1,2-o-Isopropylidene-α-D-glucofuranose exhibits anticancer properties and induces apoptosis in human cancer cells. It is an analog of aprepitant, a drug used to prevent chemotherapy-induced nausea and vomiting in cancer patients. This compound may have potential as a therapeutic agent for the treatment of various types of tumors.

CAS Number	253328-56-2
Product Name	1,2-O-Isopropylidene-alpha-D-glucofuranose
IUPAC Name	1-(6-hydroxy-2,2-dimethyl-3a,5,6,6a-tetrahydrofuro[2,3-d][1,3]dioxol-5-yl)ethane-1,2-diol
Molecular Formula	C₉H₁₆O₆
Molecular Weight	220.22
InChI	InChI=1S/C9H16O6/c1-9(2)14-7-5(12)6(4(11)3-10)13-8(7)15-9/h4-8,10-12H,3H2,1-2H3
SMILES	CC1(OC2C(C(OC2O1)C(CO)O)O)C
Synonyms	(5ξ)-1,2-O-(1-Methylethylidene)-α-D-xylo-hexofuranose;

CAS No: 18549-40-1,253328-56-2 Synonyms: Acetone-D-glucoseMonoacetone glucoseMAG MDL No: MFCD00063244 Chemical Formula: C9H16O6 Molecular Weight: 220.22

COA:

Product name: 1,2-O-Isopropylidene-α-D-glucofuranose

CAS: 18549-40-1,253328-56-2 M.F.: C₉H₁₆O₆M.W._:220.22

Quantity:100gfrom1.86 kg Batch No: 20100104

*Items*	*Standards*	*Results*
Appearance	White crystal powder	Complies
Solubility	Soluble in water, insoluble ether	Complies
Identification	IR and TLC	Complies
Melting point	150°C - 160 °C	156℃ -158 ℃
Optical Activity [α]20/D (C = 1, water)	−11° ～ −13°	-12.3°
Water	Max.0.5%	0.2%
Residue on ignition	Max. 1%	0.1%
Heavy metal	Max. 20ppm	Complies
TLC*	Should be one spot	One spot
Assay	Min. 98%	99.4%

*The stationary phase is sillica gel, the mobile phase is EtOAc and is charcoalled with 15% H₂SO₄-EtOH.

References:

1. Gramera RE, Park A, Whistler RL, J. Org. Chem. 1963, Vol28, p3230
2. Borsuk K, Frelek J, ?ysek R, Urba?czyk Z, et al., Chirality 2001, Vol13, Issue 9, p533-540

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