Sodium-D-glucuronate

D-葡萄糖醛酸钠

D-Glucuronic acid sodium salt hydrate: Definition and Background

D-Glucuronic acid sodium salt hydrate (DGASH) is a white powder that is derived from D-Glucuronic acid, which is a natural substance found in the body. DGASH is commonly used in the pharmaceutical industry, as well as in scientific research, due to its various biological properties. It is often used to enhance the solubility and stability of drugs, as well as to improve drug delivery. DGASH is also used as a precursor for the synthesis of complex biomolecules, such as glycosaminoglycans and glycoproteins.

Physical and Chemical Properties

The molecular formula of DGASH is C6H11NaO8, and it has a molecular weight of 234.14 g/mol. It is a water-soluble powder that has a melting point of 194-196°C. DGASH is an odorless and tasteless substance that is slightly acidic in nature. It has a pH range of 6.0-8.0, and it is stable at room temperature.

Synthesis and Characterization

DGASH is synthesized from D-Glucuronic acid by reacting it with sodium hydroxide (NaOH). The reaction results in the formation of DGASH as a white powder. The purity of DGASH can be determined through various analytical methods, such as high-performance liquid chromatography (HPLC) and nuclear magnetic resonance (NMR) spectroscopy.

Analytical Methods

Various analytical methods can be used to determine the purity and composition of DGASH. HPLC is commonly used to separate and quantify the components of a mixture. NMR spectroscopy is used to analyze the molecular structure of DGASH. Other methods, such as mass spectrometry and infrared spectroscopy, can also be used to analyze DGASH.

Biological Properties

DGASH has various biological properties, including anti-inflammatory, antioxidant, and anti-cancer activities. It also acts as a detoxifying agent in the liver by binding to toxins and drugs and excreting them from the body. DGASH has been shown to improve the absorption and bioavailability of drugs, as well as enhance drug delivery to specific tissues.

Toxicity and Safety in Scientific Experiments

DGASH is generally considered to be safe for use in scientific experiments. However, like any other compound, it may cause adverse effects at high doses. In vitro and in vivo studies have shown that DGASH has a low toxicity profile, and it does not have any significant adverse effects on human health.

Applications in Scientific Experiments

DGASH has various applications in scientific experiments. It is commonly used as a pharmaceutical excipient to enhance the solubility and stability of drugs. It is also used as a precursor for the synthesis of complex biomolecules, such as glycosaminoglycans and glycoproteins. DGASH has been shown to improve drug delivery to specific tissues, such as the brain.

Current State of Research

The research on DGASH is still ongoing, and it is being studied for its potential applications in various fields. Some studies have suggested that DGASH may have potential applications in the treatment of liver diseases, cancer, and neurodegenerative disorders. DGASH is also being studied for its potential use as a drug delivery system.

Potential Implications in Various Fields of Research and Industry

DGASH has potential applications in various fields, including pharmaceuticals, biotechnology, and materials science. It can be used to enhance drug delivery and improve the effectiveness of drugs. It can also be used as a precursor for the synthesis of complex biomolecules, which can have applications in tissue engineering and regenerative medicine.

Limitations and Future Directions

One of the limitations of DGASH is its low solubility in water, which can limit its applications in drug delivery. Future research can focus on developing new formulations of DGASH that can improve its solubility and stability. Another direction for future research can be to investigate the mechanisms of action of DGASH in the body, which may help to uncover new therapeutic applications for this compound. Additionally, further studies can be conducted to investigate the safety of DGASH in human populations, particularly in the long-term.