15879-93-3, a-Chloralose, CAS: 15879-93-3

15879-93-3, a-Chloralose,
CAS: 15879-93-3
C8H11Cl3O6 / 309.53
MFCD00005542

a-Chloralose, α-氯醛糖

Alpha-Chloralose is an avicide, and a rodenticide used to kill mice in temperatures below 15 °C. It is also widely used in neuroscience and veterinary medicine as an anesthetic and sedative.

Title: a-Chloralose

CAS Registry Number: 15879-93-3

CAS Name: 1,2-O-[(1R)-2,2,2-Trichloroethylidene]-a-D-glucofuranose

Additional Names: a-D-glucochloralose; glucochloral; anhydroglucochloral; chloralosane

Trademarks: Alphakil (Rentokil); Dorcalm (Frere); Somio

Molecular Formula: C8H11Cl3O6

Molecular Weight: 309.53

Percent Composition: C 31.04%, H 3.58%, Cl 34.36%, O 31.01%

Literature References: Prepd from anhydr glucose and trichloroacetaldehyde (anhydr chloral); b-chloralose is also formed. Prepn: M. Hanroit, C. Richet, C.R. Hebd. Seances Acad. Sci. 116, 63 (1893); and structure: Pictet, Reichel, Helv. Chim. Acta 6, 621 (1923); Freudenberg, Vajda, J. Am. Chem. Soc. 59, 1955 (1937); cf. Coles et al., ibid. 51, 519 (1929); White, Hixon, ibid. 55, 2438 (1933). Crystal structure: T. Taga et al., Acta Crystallogr. B38, 1874 (1982). Immobilizing agent in control of depredating birds: Redpath et al., Ann. Appl. Biol. 49, 77 (1961). Anesthetic for dogs in experimental work: B. G. Bass, N. M. Buckley, Am. J. Physiol. 210, 854 (1966); R. H. Cox, ibid. 223, 660 (1972). CNS depressant activity: J. L. Barker, Nature 252, 52 (1974). GLC determn in rodenticides: J. Theobald, J. Chromatogr. 129, 444 (1976); in tissue: E. Odam et al., Analyst 109, 1335 (1984). Acute toxicity: E. W. Schafer, Toxicol. Appl. Pharmacol. 21, 315 (1972). Review of pharmacology: G. U. Balis, R. R. Monroe, Psychopharmacologia 6, 1-30 (1964); and toxicology: P. Lees, Vet. Rec. 91, 330-333 (1972). Review as canine anesthetic: H. Holzgrefe et al., Lab. Anim. Sci. 37, 587-595 (1987).

Properties: Needles from alcohol or ether, mp 187°. [a]D22 +19° (c = 5 in 98% alc). One gram dissolves in 225 ml water at 15°, in 120 ml at 37°, in 15 ml alc at 25°. Sol in ether, glacial acetic acid; slightly in chloroform. Almost insol in petr ether. LD50 orally in mice: 400 mg/kg (Schafer).

Melting point: mp 187°

Optical Rotation: [a]D22 +19° (c = 5 in 98% alc)

Toxicity data: LD50 orally in mice: 400 mg/kg (Schafer)

Derivative Type: b-Chloralose

Properties: mp 227-230°, is much less sol in water, alcohol, and ether.

Melting point: mp 227-230°

Use: Rodenticide. Control of avian pests.

Therap-Cat: Sedative, hypnotic.

Therap-Cat-Vet: Surgical anesthetic for laboratory animals.

Keywords: Sedative/Hypnotic.

CAS Number	15879-93-3
Product Name	Chloralose
IUPAC Name	1-[(2R,3aR,5R,6S,6aR)-6-hydroxy-2-(trichloromethyl)-3a,5,6,6a-tetrahydrofuro[2,3-d][1,3]dioxol-5-yl]ethane-1,2-diol
Molecular Formula	C8H11Cl3O6
Molecular Weight	309.53 g/mol
InChI	InChI=1S/C8H11Cl3O6/c9-8(10,11)7-16-5-3(14)4(2(13)1-12)15-6(5)17-7/h2-7,12-14H,1H2/t2?,3-,4+,5+,6+,7+/m0/s1
InChI Key	OJYGBLRPYBAHRT-ZMKYHYQQSA-N
SMILES	C(C(C1C(C2C(O1)OC(O2)C(Cl)(Cl)Cl)O)O)O
Solubility	Soluble in DMSO
Synonyms	alpha Chloralose, alpha-Chloralose, Anhydroglucochloral, beta Chloralose, beta-Chloralose, Chloralose, Glucochloral, Glucochloralose
Canonical SMILES	C(C(C1C(C2C(O1)OC(O2)C(Cl)(Cl)Cl)O)O)O
Isomeric SMILES	C([C@H]([C@@H]1[C@@H]([C@@H]2[C@H](O1)O[C@@H](O2)C(Cl)(Cl)Cl)O)O)O

CAS No: 15879-93-3 Synonyms: Anhydro-D-glucochlorala-D-Glucochloralose MDL No: MFCD00005542 Chemical Formula: C8H11Cl3O6 Molecular Weight: 309.53

COA:

Name:alpha-Chloralose CAS: 15879-93-3 M.F.:C₈H₁₁Cl₃O₆ M.W._:309.53

*Items*	*Standards*	*Results*
Appearance	White powder	Positive
NMR and MS	Should comply	Comply
Appearance of solution	Dissolve0.5 gin 10 ml of ethanol, and the solution is clear	Complies
Optical Activity [α]²⁰_D (c = 2% in ethanol)	+15^o~+19^o	+17.2^o
Loss Weight On Dryness	Max. 0.5%	Complies
M.P.	178℃ ~182 ℃	180℃ ~182 ℃
Beta-Chloralose	About 15%	14.3%
Assay (Aalpha and Beta-Chloralose)	Min. 98%	99.2%