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  • 84444-90-6 ,1-甘露糖野尻霉素, Deoxymannojirimycin, D-manno-Deoxynojirimycin, CAS:84444-90-6
84444-90-6 ,1-甘露糖野尻霉素, Deoxymannojirimycin, D-manno-Deoxynojirimycin, CAS:84444-90-6

84444-90-6 ,1-甘露糖野尻霉素, Deoxymannojirimycin, D-manno-Deoxynojirimycin, CAS:84444-90-6

84444-90-6 ,1-甘露糖野尻霉素,
Deoxymannojirimycin, D-manno-Deoxynojirimycin,
CAS:84444-90-6
C6H13NO4 / 163.172
MFCD00083611

1-Deoxymannojirimycin HCl

1-甘露糖野尻霉素,

An alpha-glucosidase inhibitor with antiviral action. Derivatives of deoxynojirimycin may have anti-HIV activity.

Deoxymannojirimycin is a natural product that belongs to the group of mannojirimycins. It has been shown to have an inhibitory effect on the activity of matrix metalloproteinase-9 (MMP-9) in vitro, which is involved in the degradation of extracellular matrix. Deoxymannojirimycin also has hypoglycemic effects and can be used as a potential oral antidiabetic drug. The inhibition of MMP-9 may also be due to its binding to integrin receptors. In addition, deoxymannojirimycin has been shown to have anti-inflammatory properties in vitro and can inhibit the growth of oral pathogens, including Streptococcus mutans, Streptococcus sobrinus, and Porphyromonas gingivalis.

CAS Number84444-90-6
Product Name1-Deoxymannojirimycin
IUPAC Name(2R,3R,4R,5R)-2-(hydroxymethyl)piperidine-3,4,5-triol
Molecular FormulaC6H13NO4
Molecular Weight163.172 g/mol
InChIInChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4-,5-,6-/m1/s1
InChI KeyLXBIFEVIBLOUGU-KVTDHHQDSA-N
SMILESC1C(C(C(C(N1)CO)O)O)O
Synonyms1 Deoxymannojirimycin, 1 Deoxynojirimycin, 1 Deoxynojirimycin Hydrochloride, 1,5-Deoxy-1,5-imino-D-mannitol, 1,5-Dideoxy-1,5-imino-D-mannitol, 1-Deoxymannojirimycin, 1-Deoxynojirimycin, 1-Deoxynojirimycin Hydrochloride, Bay n 5595, Moranoline
Canonical SMILESC1C(C(C(C(N1)CO)O)O)O
Isomeric SMILESC1[C@H]([C@H]([C@@H]([C@H](N1)CO)O)O)O
CAS No: 73465-43-7,84444-90-6 Synonyms: 1,5-Dideoxy-1,5-imino-D-mannitol HCI(2R,3R,4R,5R)-2-(Hydroxymethyl)-3,4,5-piperidinetriol hydrochlorideManno-1-deoxynojirimycin hydrochloride MDL No: MFCD00083611 Chemical Formula: C6H13NO4·HCl Molecular Weight: 199.63
References: 1. Eur. J. Biochem. 1985, 150, p41-462. Sefton REB, et al., Melanoma Res. 1991, 1, p433. Suzuki SS, et al., J. Cell. Biochem. 1993, S1, p1814. Spreitz J, Stütz AE, Wrodnigg TM, Carb. Res. 2002, 337(2), p183-1865. Bischoff J, et.al., J. Biol. Chem., 1986, 261, p4766

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