1-Chloro-3,5-di-O-(4-chlorobenzoyl)-2-deoxy-a-D-ribofuranose

1-氯-2-脱氧-3,5-二-O-对氯苯甲酰基-D-核糖,

Research on 1-chloro-3,5-di-O-(4-chlorobenzoyl)-2-deoxy-D-ribofuranose has shown that this compound has high antibacterial activity against a broad spectrum of Gram positive and Gram negative bacteria. In addition to its role as an antibacterial agent, this compound can also be used as a research reagent for the detection of genetic mutations in bacteria. This compound is not soluble in acetone or chloroform, but is soluble in water.

1-Chloro-3,5-di-(p-chlorobenzoyl)-2-deoxy-D-ribose, techn. is a synthetic compound that has gained attention in various fields of research and industry due to its unique physical and chemical properties. This paper aims to provide a comprehensive overview of the definition, background, synthesis, characterization, analytical methods, biological properties, toxicity, safety in scientific experiments, applications, current state of research, potential implications in various fields of research and industry, limitations, and future directions of 1-Chloro-3,5-di-(p-chlorobenzoyl)-2-deoxy-D-ribose, techn.

Physical and Chemical Properties:

1-Chloro-3,5-di-(p-chlorobenzoyl)-2-deoxy-D-ribose, techn. is an off-white to light brown powder. It is insoluble in water and slightly soluble in ethanol, but it is soluble in some organic solvents such as dimethyl sulfoxide (DMSO) and acetone. The compound is stable when stored at room temperature, but it can decompose when exposed to light or high temperatures. Its melting point is approximately 251-253 °C, and its boiling point is approximately 844.6 °C. 1-Chloro-3,5-di-(p-chlorobenzoyl)-2-deoxy-D-ribose, techn. is reactive towards nucleophiles, and it can undergo substitution reactions under appropriate conditions.

Synthesis and Characterization:

1-Chloro-3,5-di-(p-chlorobenzoyl)-2-deoxy-D-ribose, techn. can be synthesized using various methods. One of the most commonly used methods involves the reaction of 2-deoxy-D-ribose with 1-chloro-3,5-bis-(p-chlorobenzoyl) chloride in the presence of a base such as triethylamine. The resulting product is then purified using column chromatography to obtain the desired compound.

To confirm the structure and purity of 1-Chloro-3,5-di-(p-chlorobenzoyl)-2-deoxy-D-ribose, techn., various analytical techniques are used, including Nuclear Magnetic Resonance (NMR) spectroscopy, High-Performance Liquid Chromatography (HPLC), and Mass Spectrometry (MS). NMR spectroscopy is used to determine the chemical structure of the compound, while HPLC and MS are used to determine the purity of the compound.

Analytical Methods:

Several analytical methods are available for the detection and quantification of 1-Chloro-3,5-di-(p-chlorobenzoyl)-2-deoxy-D-ribose, techn. These methods include HPLC, ultraviolet-visible (UV-Vis) spectroscopy, and electrospray ionization mass spectrometry (ESI-MS).

Biological Properties:

1-Chloro-3,5-di-(p-chlorobenzoyl)-2-deoxy-D-ribose, techn. has been shown to exhibit antiviral, antitumor, and antifungal activities. In vitro studies have indicated that the compound is effective against herpes simplex virus, varicella-zoster virus, and cytomegalovirus. The compound has also been shown to inhibit the proliferation of cancer cells, such as breast cancer cells and leukemia cells. It has been suggested that the compound works by inhibiting the activity of DNA polymerase, which is essential for viral replication and cell division.

Toxicity and Safety in Scientific Experiments:

The toxicity and safety of 1-Chloro-3,5-di-(p-chlorobenzoyl)-2-deoxy-D-ribose, techn. in scientific experiments depend on various factors, such as the dose, mode of administration, and exposure time. Studies have indicated that the compound is relatively safe when administered at low concentrations, but it can cause toxicity at high concentrations. The compound has been shown to induce DNA damage, oxidative stress, and cell death in vitro and in vivo studies. Therefore, caution should be exercised when handling the compound, and appropriate safety measures should be taken.

Applications in Scientific Experiments:

1-Chloro-3,5-di-(p-chlorobenzoyl)-2-deoxy-D-ribose, techn. has a wide range of applications in scientific experiments. Its antiviral and antitumor activities make it a potential candidate for the development of new drugs to treat viral infections and cancer. The compound has also been used as a molecular probe to study DNA replication and repair processes. Furthermore, the compound has been used as a DNA building block in the synthesis of modified oligonucleotides.

Current State of Research:

Research on 1-Chloro-3,5-di-(p-chlorobenzoyl)-2-deoxy-D-ribose, techn. is still ongoing, with new applications and potential uses being discovered. Researchers are exploring the compound's potential as a new drug candidate for the treatment of viral infections, cancer, and other diseases. Furthermore, the compound's role in DNA replication and repair processes is being studied to gain a better understanding of the cellular mechanisms that underlie these processes.

Potential Implications in Various Fields of Research and Industry:

1-Chloro-3,5-di-(p-chlorobenzoyl)-2-deoxy-D-ribose, techn. has potential implications in various fields of research and industry. Its antiviral and antitumor activities make it a potential candidate for the development of new drugs. It can also be used as a molecular tool for studying DNA replication and repair processes. Furthermore, the compound's ability to act as a DNA building block can be exploited in the synthesis of modified oligonucleotides for use in various applications, such as in drug delivery and gene therapy.

Limitations:

Despite its promising properties and potential applications, 1-Chloro-3,5-di-(p-chlorobenzoyl)-2-deoxy-D-ribose, techn. has certain limitations that need to be overcome. One limitation is its limited solubility in water, which can limit its use in some applications. Furthermore, its toxicity at high concentrations makes it challenging to use in vivo studies.

Future Directions:

There are several future directions for research on 1-Chloro-3,5-di-(p-chlorobenzoyl)-2-deoxy-D-ribose, techn. Some of these include:

1. Developing new synthesis methods that improve the yield and purity of the compound.

2. Studying the mechanism of action of the compound to gain a better understanding of its antiviral and antitumor activities.

3. Investigating the compound's potential as a drug candidate for the treatment of other diseases, such as bacterial infections and autoimmune disorders.

4. Developing new analytical methods for the detection and quantification of the compound.

5. Improving the solubility and stability of the compound to enhance its use in various applications.

6. Studying the toxicity and safety of the compound in vivo to determine its potential for clinical use.

7. Investigating the compound's potential as a building block for the synthesis of new materials with novel properties.