19026-22-3 ,2-Acetamido-2-deoxy-D-glucono-1,5-lactone,
2-乙酰氨基-2-脱氧-D-葡萄糖酸-1,5-内酯,
CAS:19026-22-3
C8H13NO6 / 219.19
MFCD00076154
2-乙酰氨基-2-脱氧-D-葡萄糖酸-1,5-内酯,
2-Acetamido-2-deoxy-D-glucono-1,5-lactone is a diagnostic agent that inhibits the activities of enzymes such as protein synthesis and cell division. It can be used to identify viral infections in animals, plants and marine microorganisms. 2-Acetamido-2-deoxy-D-glucono-1,5-lactone has been shown to inhibit the biochemical activity of enzymes in cells grown in culture. 2AADG is also a diagnostic agent that can be used to detect tumors in subcutaneous tissues due to its ability to inhibit the production of proteins essential for cell division.
2-Acetamido-2-deoxy-D-glucono-1,5-lactone, also known as N-acetylglucosaminic acid, is an important carbohydrate and a precursor to a wide variety of biomolecules. It is derived from glucose, and forms the structural backbone of many important molecules such as chitin, hyaluronic acid, and heparan sulfate. It is also a key component of the immune system, as it is involved in the recognition and response to invading pathogens.
Synthesis and Characterization:
2-Acetamido-2-deoxy-D-glucono-1,5-lactone can be synthesized from glucose in a number of different ways, including enzymatic and chemical methods. The enzymatic method involves the use of enzymes such as N-acetylglucosaminidase and uridine diphosphate N-acetylglucosamine pyrophosphorylase, while the chemical method involves the use of reagents such as acetic anhydride and sodium hydroxide.
Characterization of 2-Acetamido-2-deoxy-D-glucono-1,5-lactone can be done using a number of different techniques, including nuclear magnetic resonance (NMR) spectroscopy, mass spectrometry, and X-ray crystallography.
Analytical Methods:
Several analytical methods can be used to detect and quantify 2-Acetamido-2-deoxy-D-glucono-1,5-lactone in various samples, including chromatography (HPLC, GC), colorimetry, and electrophoresis.
Biological Properties:
2-Acetamido-2-deoxy-D-glucono-1,5-lactone is involved in a number of different biological processes, including the formation of the extracellular matrix, chitin synthesis, and the regulation of the immune system. It is also involved in the biosynthesis of glycosaminoglycans, which are important components of cartilage and other connective tissues.
Toxicity and Safety in Scientific Experiments:
There is currently no evidence to suggest that 2-Acetamido-2-deoxy-D-glucono-1,5-lactone is toxic or harmful in scientific experiments. However, as with any compound, proper safety procedures should be followed to minimize the risk of exposure.
Applications in Scientific Experiments:
2-Acetamido-2-deoxy-D-glucono-1,5-lactone has a wide range of applications in scientific experiments, including the synthesis of glycosaminoglycans, the formation of chitin, and the regulation of the immune system. It can also be used as a substrate for various enzymes, including N-acetylglucosaminidase.
Current State of Research:
Research on 2-Acetamido-2-deoxy-D-glucono-1,5-lactone is ongoing, with many studies focused on its role in the immune system and in the biosynthesis of glycosaminoglycans. Other areas of research include the synthesis and characterization of new derivatives of 2-Acetamido-2-deoxy-D-glucono-1,5-lactone, and the development of new analytical methods for its detection and quantification.
Potential Implications in Various Fields of Research and Industry:
The potential implications of 2-Acetamido-2-deoxy-D-glucono-1,5-lactone are vast, with applications in fields such as medicine, agriculture, and materials science. For example, it could be used to synthesize new glycosaminoglycans for use in tissue engineering and regenerative medicine, or as a component in novel biomaterials.
Limitations and Future Directions:
One limitation of 2-Acetamido-2-deoxy-D-glucono-1,5-lactone research is the lack of standardization in its synthesis and characterization. Additionally, more studies are needed to fully understand its role in the immune system and its potential as a therapeutic target. Future directions include the development of new analytical methods for its detection and quantification, and the exploration of its role in the biosynthesis of other important biomolecules.
Other possible future directions include the synthesis of new derivatives of 2-Acetamido-2-deoxy-D-glucono-1,5-lactone for use in industry and medicine, and the development of new methods for its large-scale production. Additionally, continued research on the biological properties and potential applications of 2-Acetamido-2-deoxy-D-glucono-1,5-lactone may lead to the discovery of new uses for this important carbohydrate.
CAS Number | 19026-22-3 |
Product Name | 2-Acetamido-2-deoxy-D-glucono-1,5-lactone |
IUPAC Name | N-[(3R,4R,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-2-oxooxan-3-yl]acetamide |
Molecular Formula | C8H13NO6 |
Molecular Weight | 219.19 g/mol |
InChI | InChI=1S/C8H13NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-7,10,12-13H,2H2,1H3,(H,9,11)/t4-,5-,6-,7-/m1/s1 |
InChI Key | NELQYZRSPDCGRQ-DBRKOABJSA-N |
SMILES | CC(=O)NC1C(C(C(OC1=O)CO)O)O |
Synonyms | 2-acetamido-2-deoxy-1,5-gluconolactone, 2-acetamido-2-deoxy-D-glucono-(1,5)-lactone, CD 80110, CD-80110 |
Canonical SMILES | CC(=O)NC1C(C(C(OC1=O)CO)O)O |
Isomeric SMILES | CC(=O)N[C@@H]1[C@H]([C@@H]([C@H](OC1=O)CO)O)O |
CAS No: 19026-22-3 MDL No: MFCD00076154 Chemical Formula: C8H13NO6 Molecular Weight: 219.19 |
References: 1. Sasaki K, et al., Proc. NatI. Acad. Sci. 1997, 94, p14294 |
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