S-(2E)-2-Octenoate coenzyme A

(2E)-Octenoyl-CoA, also known as (E)-S-2-octenoate, belongs to the class of organic compounds known as medium-chain 2-enoyl coas. These are organic compounds containing a coenzyme A substructure linked to a medium-chain 2-enoyl chain of 5 to 12 carbon atoms (2E)-Octenoyl-CoA is slightly soluble (in water) and an extremely strong acidic compound (based on its pKa) (2E)-Octenoyl-CoA has been primarily detected in urine. Within the cell, (2E)-octenoyl-CoA is primarily located in the cytoplasm (2E)-Octenoyl-CoA exists in all eukaryotes, ranging from yeast to humans. In humans, (2E)-octenoyl-CoA is involved in the fatty acid metabolism pathway (2E)-Octenoyl-CoA is also involved in several metabolic disorders, some of which include the mitochondrial Beta-oxidation OF short chain saturated fatty acids pathway, the mitochondrial Beta-oxidation OF medium chain saturated fatty acids pathway, very-long-chain acyl CoA dehydrogenase deficiency (vlcad), and long chain acyl-CoA dehydrogenase deficiency (lcad).

S-2-Octenoate CoA is a natural ligand for the orphan G protein-coupled receptor GPR120. This ligand has been shown to activate AMPK and PPARα, leading to increased fatty acid oxidation and decreased lipid synthesis. Studies have shown that S-2-octenoate coenzyme A inhibits the production of inflammatory cytokines, such as IL-6, IL-1β, TNFα and IFNγ. It also inhibits the migration of leukocytes and platelets. The high purity of this ligand ensures minimal background interference in immunoassays.